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But what about human diseases Despite leakiness, vaccination may reduce pathogen load, affecting disease transmission dynamics Most human vaccines in use today aren't leaky
Making a difference - identifying severe side effect of Covid-19 vaccine | UCLH Biomedical
They are very good at stopping disease transmission This leakiness is concerning because it increases vaccination coverage required to prevent disease spread and can promote evolution of increased pathogen virulence But as researchers turn to diseases that are more difficult to protect against, such as malaria or hiv, they are setting their sights lower, aiming for vaccines that prevent severe disease but not infection.
The direct effects of these vaccines at the individual level are given in their descriptions, but the indirect protection that they confer as a result of reduction in disease transmission (herd immunity) is not so easily surmised from individual effects.
A leaky vaccine removes this pressure to become less virulent As the pathogen passes between vaccinated hosts, it can gain virulence without killing them — with severe consequences for any. Media coverage of a recent study involving a leaky vaccine raised questions about the possibility that they could make viruses more dangerous. The possible effect of 'leaky vaccines' on how viruses spread is an interesting new observation
But there are a number of other ways by which viruses can change in response to vaccination, writes. Feline calicivirus, which causes a respiratory infection in cats, also appears to have increased in virulence as a result of vaccination, read says, and he is worried about the same thing happening with avian influenza, which some countries keep at bay with poultry vaccines Many livestock and human vaccines are leaky because they block symptoms but do not prevent infection or onward transmission
